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INPP4A encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate.
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this study shows that the myeloid Inpp4a-knockout mice display impaired bacteria clearance due to decreased inflammatory cytokine production
this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1 (Montrer INPP5D Anticorps)/2 and Inpp4a, and accelerates phagosome acidification
This study showed that spontaneous Inpp4a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
These results suggest a novel mechanism of action of resveratrol in attenuating asthma phenotype by downregulating PI3K-Akt (Montrer AKT1 Anticorps) pathway via upregulating INPP4A.
INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death
Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate (Montrer GRIN1 Anticorps) excitotoxicity initiated by the climbing fiber, and that Eaat4 (Montrer SLC1A6 Anticorps) may exert a protective effect.
Study provides the first evidence that inositol polyphosphate 4-phosphatase-1 controls the activation of Akt (Montrer AKT1 Anticorps) and thereby cell proliferation, survival and tumorigenesis.
Our findings indicate that upregulation of miR (Montrer MLXIP Anticorps)-935 may promote pancreatic cancer cell proliferation and migration and inhibit cell apoptosis by targeting INPP4A.
INPP4A could possibly serve as a candidate gene for alterations associated with asbestos exposure.
Data adds a new etiology to the spectrum of hindbrain malformations in human, and when presented with myoclonic epilepsy may lead to the clinical suspicion of INPP4A defect.
The +110832A/G (Thr (Montrer TRH Anticorps)/Ala) variant of INPP4A was significantly associated with asthma in an Indian population.
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.
inositol polyphosphate 4-phosphatase type I
, inositol polyphosphate-4-phosphatase, type 1
, inositol polyphosphate-4-phosphatase, type I, 107kD
, type I inositol 3,4-bisphosphate 4-phosphatase
, type I inositol-3,4-bisphosphate 4-phosphatase