anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) Anticorps

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. De plus, nous expédions Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
KCNC1 16502 P15388
KCNC1 25327 P25122
KCNC1 3746 P48547
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Top anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 165 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Souris Lapin Inconjugué DB, IHC (fro), IF, WB 0.1 mL 6 to 8 Days
$473.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-KCNC1 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate 100 μL 2 to 3 Days
$249.00
Détails
Souris Lapin Inconjugué WB Observed bind size: 58KD 100 μg 4 to 6 Days
$240.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Western blot analysis of Kv3.1 expression in HepG2 (A), rat brain (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Rat Lapin Inconjugué IHC, WB IHC staining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503  Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA. IHC staining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503  Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA. 100 μL 3 to 4 Days
$508.20
Détails
Humain Souris Inconjugué AA, ICC, IF, IHC, WB 100 μg 3 to 4 Days
$453.70
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western Blot (WB) analysis of specific cells using KV3.1 Polyclonal Antibody. 100 μL Disponible
$363.46
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μL 11 to 14 Days
$507.83
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis of extracts from JK cells, using KCNC1 antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6275379 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB 0.1 mg 6 to 8 Days
$467.50
Détails

anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Anticorps mieux référencés

  1. Mouse (Murine) Polyclonal KCNC1 Primary Antibody pour IHC (fro), IHC - ABIN152620 : Burger, Ribera: Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 (PubMed)
    Show all 6 Pubmed References

  2. Mouse (Murine) Polyclonal KCNC1 Primary Antibody pour DB, IHC (fro) - ABIN372706 : Ezzeddine, Glanzman: Prolonged habituation of the gill-withdrawal reflex in Aplysia depends on protein synthesis, protein phosphatase activity, and postsynaptic glutamate receptors. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 (PubMed)
    Show all 10 Pubmed References

  3. Cow (Bovine) Polyclonal KCNC1 Primary Antibody pour BP, IP - ABIN452090 : Chen, Wang, Rong, Wang, Wang: Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats. dans Acta pharmaceutica Sinica. B 2015 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal KCNC1 Primary Antibody pour WB - ABIN538246 : Rettig, Wunder, Stocker, Lichtinghagen, Mastiaux, Beckh, Kues, Pedarzani, Schröter, Ruppersberg: Characterization of a Shaw-related potassium channel family in rat brain. dans The EMBO journal 1992 (PubMed)
    Show all 3 Pubmed References

  5. Mouse (Murine) Polyclonal KCNC1 Primary Antibody pour IHC (fro), IF - ABIN550213 : Pongs: Voltage-gated potassium channels: from hyperexcitability to excitement. dans FEBS letters 1999 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 partenaires d’interaction

Mouse (Murine) Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) interaction partners

  1. Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation.

  2. The resting (closed) Kv3.1 channel conformation forms the high-affinity state for gambierol.

  3. high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail.

  4. Although all Kv3 transcripts were significantly expressed at embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 subunit proteins were present, suggesting a novel role for Kv3 channels at this developmental stage.

  5. Block of Kv3.1 channels hinders spike repolarization and severely depresses evoked fast firing in deep cerebellar nuclear neurons.

  6. Mice lacking both Kcnc1 and Kcnc2 genes fail to express the Kv3.1 and Kv3.2 channels in in the suprachiasmatic nucleus.

  7. These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels.

  8. As Kcnc1, but not Kcnc3, alleles are lost, mutant mice exhibit increasing gait ataxia accompanied by spike broadening and deceleration in deep cerebellar nuclei. neurons.

  9. interaction with CALP/KCHIP4

  10. NCS-1 is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium.

  11. Kv4.3, in association with K(+) channel-interacting proteins, is the major molecular determinant of A-type potassium current in murine colonic myocytes.

  12. Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons.

  13. Motor deficits and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in Kv3.1 knockout mice.

  14. Ongoing activity in auditory brainstem neurons is necessary for the maintenance of Kv3.1 tonotopicity through the CREB pathway

  15. Double mutant Kv3.1/Kv3.3-deficient mice are constitutively hyperactive. Increased ambulatory and stereotypic activity in conjunction with sleep loss was seen in Kv3.1-single mutants but not in Kv3.3-single mutants.

  16. Starburst amacrine cells have large outward currents which are mediated in part by the Kv3.1 channel.

  17. all Renshaw cells expressed Kv3.1b weakly from postnatal day 14, and strongly at postnatal day 21.

  18. two voltage-gated potassium channels, Kv3.1 and Kv3.3, control sleep in wild-type and Kv3-mutant mice

  19. Calcineurin and NFATc3 constitute a Ca(2+)-driven signaling module that contributes to the nonuniform distribution of Kv4 expression, and hence Ito function, in the mouse left ventricle.

  20. K(V)3.1 K(+) current accounts for significant component of total K(+) current in oligodendrocyte lineage and, in association with OSP/claudin-11, plays significant role in OPC proliferation and migration and myelination of axons.

Human Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) interaction partners

  1. polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca(2+) regulation of Kv4 channels

  2. A recurrent de novo mutation in KCNC1 (c.959G>A, p.Arg320His) has been identified recently as one of the important genetic causes of progress myoclonic epilepsy. This recurrent mutation in KCNC1 was identified in the two brothers who showed characteristic features of myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK). The asymptomatic mother was suspected as being mosaic for this mutation.

  3. KNCN1 p.R320H mutation causes MEAK syndrome.

  4. A nonsense variant in KCNC1 gene was identified in three family members with intellectual disability without seizures.

  5. reviews the phenotype/genotype of progressive myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK)associated with KCNC1 mutations [review]

  6. KCNC1 produces a resurgent current during repolarization, ensuring enough repolarizing power to terminate each action potential. The current results from a combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation.

  7. A recurrent KCNC1 de novo mutation, c.959G>A (p.Arg320His), is a new major cause for progressive myoclonus epilepsy. It has a dominant-negative loss-of-function effect.

  8. Findings show a decrease in Kv3.1b channel protein in schizophrenia neocortex, a deficit that is restored by antipsychotic drugs

  9. Describes localization in mouse brain of two isoforms - the longer is called b and the shorter is called a.

  10. Describes two rat isoforms of Kv3.1, alpha is the longer one and beta is the shorter one

  11. KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation.

  12. Although all KV3 subunit transcripts are significantly expressed at embryonic age in whole mouse brain extracts, only KV3.1, KV3.2 and KV3.4 subunit transgenic proteins are present.

  13. demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels

  14. Kv3.1 channels are transported into axons by binding to kinesin I.

  15. In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 or Kv3.2b channels and Kv1.5 Arg487Tyr/Val, but not wild-type channels.

Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) profil antigène

Profil protéine

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Multiple transcript variants encoding different isoforms have been inferred for this gene based on orthologous loci.

Gene names and symbols associated with KCNC1

  • potassium voltage-gated channel subfamily C member 1 (KCNC1) anticorps
  • potassium voltage-gated channel, Shaw-related subfamily, member 1 (kcnc1) anticorps
  • potassium voltage gated channel, Shaw-related subfamily, member 1 (Kcnc1) anticorps
  • potassium voltage-gated channel subfamily C member 1 (Kcnc1) anticorps
  • potassium voltage-gated channel, Shaw-related subfamily, member 1a (kcnc1a) anticorps
  • C230009H10Rik anticorps
  • KCNC2 anticorps
  • Kcr2-1 anticorps
  • KShIIIB anticorps
  • KV3.1 anticorps
  • Kv4 anticorps
  • NGK2 anticorps
  • NGK2-KV4 anticorps
  • Shaw anticorps
  • zgc:194940 anticorps
  • zgc:194950 anticorps

Protein level used designations for KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1 , potassium channel Kv3.1 , potassium voltage-gated channel subfamily C member 1 , voltage-gated potassium channel subunit Kv3.1 , voltage-gated potassium channel subunit Kv4 , NGK2 , RAW2 , potassium channel gene 1 , voltage-gated potassium channel protein KV3.1 , Shaw-related voltage-gated potassium channel protein 1 , potassium channel , voltage-gated potassium channel KCNC1 , kcnc1 , voltage-gated potassium channel Kv3.1a

GENE ID SPECIES
466452 Pan troglodytes
100020061 Monodelphis domestica
100056567 Equus caballus
100144433 Taeniopygia guttata
100144936 Xenopus (Silurana) tropicalis
16502 Mus musculus
25327 Rattus norvegicus
3746 Homo sapiens
423076 Gallus gallus
403705 Canis lupus familiaris
541459 Bos taurus
100008968 Oryctolagus cuniculus
565419 Danio rerio
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