IL-6 anticorps (AA 30-212)

N° du produit ABIN1513075

Détail du produit anti-IL-6 anticorps

Antigène: IL-6 (IL6) (Interleukin 6 (IL6))

Épitope: AA 30-212

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE SSKEALAENN LNLPKMAEKD GCFQSGFNEE TCLVKIITGL LEFEVYLEYL QNRFESSEEQ ARAVQMSTKV LIQFLQKKAK NLDAITTPDP TTNASLLTKL QAQNQWLQDM TTHLILRSFK EFLQSSLRAL RQM

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human IL6 (NP_000591.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-IL-6 (ABIN1513075)

Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." dans: Pharmacological research, Vol. 133, pp. 218-235, (2018) (PubMed).

Chen, Yu, Yuan, Zhang, Fan, Yuan, Zhang, Yao: "Enriched housing promotes post-stroke functional recovery through astrocytic HMGB1-IL-6-mediated angiogenesis." dans: Cell death discovery, Vol. 3, pp. 17054, (2017) (PubMed).

Meng, Zhang, Shi, Zhang, Yuan: "Inhibition of interleukin-6 abolishes the promoting effects of pair housing on post-stroke neurogenesis." dans: Neuroscience, Vol. 307, pp. 160-70, (2016) (PubMed).

Liu, Lu, Zhou, Xu, Chen: "Flexible gold electrode array for multiplexed immunoelectrochemical measurement of three protein biomarkers for prostate cancer." dans: ACS applied materials & interfaces, Vol. 6, Issue 22, pp. 20137-43, (2014) (PubMed).

Détails sur IL-6

Antigène: IL-6 (IL6) (Interleukin 6 (IL6))

Autre désignation: IL6 (IL6 Produits)

Synonymes: anticorps BSF2, anticorps HGF, anticorps HSF, anticorps IFNB2, anticorps IL-6, anticorps Il-6, anticorps ILg6, anticorps Ifnb2, anticorps il6, anticorps CHIL-6, anticorps interleukin 6, anticorps interleukin-6, anticorps IL6, anticorps Il6, anticorps il-6, anticorps IL-6

Sujet: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.,IL6,BSF-2,BSF2,CDF,HGF,HSF,IFN-beta-2,IFNB2,IL-6,Cancer,Tumor immunology,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Growth factor,Endocrine & Metabolism,Endocrine and metabolic diseases,Metabolic disorders,Obesity,Immunology & Inflammation,Cytokines,Interleukins,IL-6 Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Neurodegenerative Diseases Markers,Other Neurological disorders,Cardiovascular,Angiogenesis,Angiogenic growth factors,IL6

Poids moléculaire: 23 kDa

ID gène: 3569

UniProt: P05231

Pathways: Signalisation TLR, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome