STAT5B anticorps (AA 40-280)

N° du produit ABIN1513572

Détail du produit anti-STAT5B anticorps

Antigène: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Épitope: AA 40-280

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAT5B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: SQAWDSVDLD NPQENIKATQ LLEGLVQELQ KKAEHQVGED GFLLKIKLGH YATQLQNTYD RCPMELVRCI RHILYNEQRL VREANNGSSP AGSLADAMSQ KHLQINQTFE ELRLVTQDTE NELKKLQQTQ EYFIIQYQES LRIQAQFGPL AQLSPQERLS RETALQQKQV SLEAWLQREA QTLQQYRVEL AEKHQKTLQL LRKQQTIILD DELIQWKRRQ QLAGNGGPPE GSLDVLQSWC E

Réactivité croisée: Humain, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human STAT5B (NP_036580.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:20 - 1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-STAT5B (ABIN1513572)

Zheng, Xiong, Wu, Chen, Chen, Fleming, Gao, Bi, Ge: "Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells." dans: Molecular & cellular proteomics : MCP, Vol. 14, Issue 6, pp. 1447-63, (2015) (PubMed).

Détails sur STAT5B

Antigène: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Autre désignation: STAT5B (STAT5B Produits)

Synonymes: anticorps STAT5, anticorps stat5, anticorps STAT5A, anticorps STAT5B, anticorps signal transducer and activator of transcription 5B, anticorps signal transducer and activator of transcription 5B S homeolog, anticorps Signal transducer and activator of transcription 5B, anticorps STAT5B, anticorps Stat5b, anticorps stat5b.S, anticorps LOC490969, anticorps sta5b, anticorps LOC100566752, anticorps LOC100052954

Sujet: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.,STAT5,STAT5B,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,STAT5B

Poids moléculaire: 89 kDa

ID gène: 6777

UniProt: P51692

Pathways: Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation