GRB2 anticorps (C-Term)

N° du produit ABIN264897

Détail du produit anti-GRB2 anticorps

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Épitope: AA 198-217, C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody recognizes Grb2, a highly conserved approximately 26 kDa adaptor protein.

Purification: Immunoaffinity chromatography

Immunogène: Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217)

Isotype: IgG

Information d'application

Indications d'application: Western blot (1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C for longer.

Détails sur GRB2

Antigène: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Autre désignation: GRB2 / ASH (GRB2 Produits)

Synonymes: anticorps GRB2, anticorps grb2, anticorps AA408164, anticorps Ash, anticorps ASH, anticorps EGFRBP-GRB2, anticorps Grb3-3, anticorps MST084, anticorps MSTP084, anticorps NCKAP2, anticorps wu:fb18e12, anticorps wu:fb34e06, anticorps zgc:73077, anticorps growth factor receptor bound protein 2, anticorps growth factor receptor-bound protein 2, anticorps growth factor receptor-bound protein 2b, anticorps GRB2, anticorps grb2, anticorps Grb2, anticorps grb2b

Sujet: Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.Synonyms: Growth factor receptor-bound protein 2

ID gène: 2885

NCBI Accession: NP_002077

UniProt: P62993

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation