TRKA anticorps (Extracellular Domain)

N° du produit ABIN285990

Détail du produit anti-TRKA anticorps

Antigène: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Épitope: Extracellular Domain

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRKA est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Réactivité croisée: Humain, Souris

Réactivité croisée (Details): Reacts with Rat, Mouse and Human. Reactivity to other species is unknown. Recognizes TrkA, Mr 140 kDa. Does not crossreact with TrkB or TrkC.

Purification: Protein A affinity chromatography

Immunogène: TrkA antibody was raised in rabbit using recombinant protein corresponding to extracellular domain of rat TrkA receptor as the immunogen.

Isotype: IgG

Information d'application

Indications d'application: Optimal conditions should be determined byt he investigator.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: 20 mM PO4 buffer, pH 7.6, with 250 M NaCl and 0.1 % NaN3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C.

Détails sur TRKA

Antigène: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Autre désignation: TrkA (NTRK1 Produits)

Synonymes: anticorps MTC, anticorps TRK, anticorps TRK1, anticorps TRKA, anticorps Trk-A, anticorps p140-TrkA, anticorps CDHF12, anticorps CDHR16, anticorps HSCR1, anticorps MEN2A, anticorps MEN2B, anticorps MTC1, anticorps PTC, anticorps RET-ELE1, anticorps RET51, anticorps Trk, anticorps C80751, anticorps Tkr, anticorps TrkA, anticorps trk, anticorps trka, anticorps CTRKA, anticorps trkA, anticorps neurotrophic receptor tyrosine kinase 1, anticorps ret proto-oncogene, anticorps neurotrophic tyrosine kinase, receptor, type 1, anticorps NTRK1, anticorps RET, anticorps Ntrk1, anticorps ntrk1

Sujet: TrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, Tr kb, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins.

Poids moléculaire: 140 kDa (predicted detection band MW)

Pathways: Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process