MDM2 anticorps (Middle Region)

N° du produit ABIN5517680

Détail du produit anti-MDM2 anticorps

Antigène: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDM2 est non-conjugé

Application: Western Blotting (WB)

Séquence: EISLADYWKC TSCNEMNPPL PSHCNRCWAL RENWLPEDKG KDKGEISEKA

Attributs du produit: This is a rabbit polyclonal antibody against MDM2. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human MDM2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MDM2

Antigène: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Autre désignation: MDM2 (MDM2 Produits)

Synonymes: anticorps ACTFS, anticorps HDMX, anticorps hdm2, anticorps zgc:109834, anticorps 1700007J15Rik, anticorps AA415488, anticorps Mdm-2, anticorps MDM2 proto-oncogene, anticorps MDM2 proto-oncogene S homeolog, anticorps Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse), anticorps MDM2 oncogene, E3 ubiquitin protein ligase, anticorps transformed mouse 3T3 cell double minute 2, anticorps MDM2, anticorps mdm2.S, anticorps Mdm2, anticorps mdm2

Sujet: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Alias Symbols: MDM2,

Protein Interaction Partner: RPS7, RPS6, RPL26, UBE2D3, UBE2D2, UBE2D1, UBC, CDKN2A, HDAC1, TSC22D3, DAPK3, PARP1, PML, ARIH2, RPL23, KAT2B, AATF, RCHY1, DLAT, DHX9, DDX5, DAXX, U19, HRNR, OGDH, NCL, HNRNPM, MDM4, MDM2, ILF3, IFI16, IARS, HSP90AB1, HSP90AA1, HSPA8, HNRNPU, GTF2I, PER

Protein Size: 446

ID gène: 4193

Pathways: Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway