SHC1 anticorps (AA 347-351)

N° du produit ABIN5689404

Détail du produit anti-SHC1 anticorps

Antigène: SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))

Épitope: AA 347-351

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHC1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous level of total Shc1 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Shc1 (Ab-349) antibody was raised against a peptide sequence around aa.347~351 (H-Q-Y-Y-N) derived from Human Shc1.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur SHC1

Antigène: SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))

Autre désignation: Shc1 (SHC1 Produits)

Synonymes: anticorps SHC1, anticorps SHC, anticorps SHCA, anticorps P66shc, anticorps si:dkey-246i14.4, anticorps wu:fc10h03, anticorps shc, anticorps p66shc, anticorps Shc, anticorps ShcA, anticorps p66, anticorps SHC adaptor protein 1, anticorps Shc1p, anticorps squalene--hopene cyclase, anticorps SHC (Src homology 2 domain containing) transforming protein 1, anticorps SHC (Src homology 2 domain containing) transforming protein 1 L homeolog, anticorps src homology 2 domain-containing transforming protein C1, anticorps SHC1, anticorps shc1, anticorps Shc1, anticorps shc1.L

Sujet: Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span

Poids moléculaire: 46, 52, 66 kDa

ID gène: 6464

NCBI Accession: NP_001123512

UniProt: P29353

Pathways: Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2