MDM2 anticorps (AA 18-22)

N° du produit ABIN5689626

Détail du produit anti-MDM2 anticorps

Antigène: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Épitope: AA 18-22

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDM2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of total MDM2 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: MDM2 antibody was raised against a peptide sequence around aa.18~22 (Q-I-P-A-S) derived from Human MDM2. .

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur MDM2

Antigène: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Autre désignation: MDM2 (MDM2 Produits)

Synonymes: anticorps ACTFS, anticorps HDMX, anticorps hdm2, anticorps zgc:109834, anticorps 1700007J15Rik, anticorps AA415488, anticorps Mdm-2, anticorps MDM2 proto-oncogene, anticorps MDM2 proto-oncogene S homeolog, anticorps Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse), anticorps MDM2 oncogene, E3 ubiquitin protein ligase, anticorps transformed mouse 3T3 cell double minute 2, anticorps MDM2, anticorps mdm2.S, anticorps Mdm2, anticorps mdm2

Sujet: MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 .

Poids moléculaire: 90 kDa

ID gène: 4193

NCBI Accession: NP_002383

UniProt: Q00987

Pathways: Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway