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GRB2 anticorps (C-Term)

GRB2 Reactivité: Humain, Souris, Rat, Boeuf (Vache) WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN615588
  • Antigène Voir toutes GRB2 Anticorps
    GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
    Épitope
    • 8
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 198-217, C-Term
    Reactivité
    • 64
    • 31
    • 30
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache)
    Hôte
    • 50
    • 11
    • 3
    Lapin
    Clonalité
    • 51
    • 12
    • 1
    Polyclonal
    Conjugué
    • 45
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GRB2 est non-conjugé
    Application
    • 49
    • 33
    • 20
    • 11
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa adaptor protein.
    Purification
    Immunoaffinity Chromatography
    Immunogène
    GRB2 antibody was raised against synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217). .Remarks: 100% identity between man, cow, rat and mouse
    Top Product
    Discover our top product GRB2 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 15 mM sodium azide and 0.2 % BSA
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
    Autre désignation
    GRB2 / ASH (GRB2 Produits)
    Synonymes
    anticorps GRB2, anticorps grb2, anticorps AA408164, anticorps Ash, anticorps ASH, anticorps EGFRBP-GRB2, anticorps Grb3-3, anticorps MST084, anticorps MSTP084, anticorps NCKAP2, anticorps wu:fb18e12, anticorps wu:fb34e06, anticorps zgc:73077, anticorps growth factor receptor bound protein 2, anticorps growth factor receptor-bound protein 2, anticorps growth factor receptor-bound protein 2b, anticorps GRB2, anticorps grb2, anticorps Grb2, anticorps grb2b
    Sujet
    Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.Synonyms: Growth factor receptor-bound protein 2
    ID gène
    2885
    NCBI Accession
    NP_002077
    UniProt
    P62993
    Pathways
    Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
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