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PTPN11 anticorps (AA 526-551)
PTPN11
Reactivité: Humain
WB, IHC (p), FACS
Hôte: Lapin
Polyclonal
RB21493
unconjugated
N° du produit ABIN6243732
Détail du produit anti-PTPN11 anticorps
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Antigène
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PTPN11
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
Épitope
Tous les épitopes à travers PTPN11 Anticorps.
AA 526-551
Reactivité
Toutes les réactivités sur PTPN11 Anticorps
Humain
Hôte
Toutes les hôtes sur PTPN11 Anticorps
Lapin
Clonalité
Toutes les clonalités sur PTPN11 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers PTPN11 Anticorps
Cet anticorp PTPN11 est non-conjugé
Application
Tous les applications à travers PTPN11 Anticorps.
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
Homologie
C, M, Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This SHP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 526-551 amino acids from human SHP2.
Clone
RB21493
Isotype
Ig Fraction
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Information d'application
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Indications d'application
WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Références pour anticorps anti-PTPN11 (ABIN6243732)
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Chang, Gao, Han, Du, Liu, Wang, Tan, Zhang, Liu, Zhu, Yu, Fan, Zhang, Zhou, Wang, Fu, Cao : "Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma. " dans: Gut , Vol. 63 , Issue 9 , pp. 1457-67 , (2014 ) (PubMed ).
Détails sur PTPN11
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Antigène
PTPN11
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
Autre désignation
SHP2 (PTPN11 Produits )
Synonymes
anticorps BPTP3, anticorps CFC, anticorps NS1, anticorps PTP-1D, anticorps PTP2C, anticorps SH-PTP2, anticorps SH-PTP3, anticorps SHP2, anticorps 2700084A17Rik, anticorps AW536184, anticorps PTP1D, anticorps SAP-2, anticorps SHP-2, anticorps Shp2, anticorps Syp, anticorps SYP, anticorps bptp3, anticorps cfc, anticorps ns1, anticorps ptp-2, anticorps ptp2c, anticorps ptpn11, anticorps ptpn11-a, anticorps ptpn11-b, anticorps shp-2, anticorps shp2, anticorps fa14b09, anticorps wu:fa14b09, anticorps wu:fi24f03, anticorps zgc:55388, anticorps zgc:63553, anticorps protein tyrosine phosphatase, non-receptor type 11, anticorps protein tyrosine phosphatase, non-receptor type 11 S homeolog, anticorps protein tyrosine phosphatase, non-receptor type 11, a, anticorps protein tyrosine phosphatase, non-receptor type 11, b, anticorps PTPN11, anticorps Ptpn11, anticorps ptpn11.S, anticorps ptpn11a, anticorps ptpn11b
Classe de substances
Viral Protein
Sujet
SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Poids moléculaire
68011
NCBI Accession
NP_002825 , NP_542168
UniProt
Q06124
Pathways
Signalistation JAK/STAT , Signalisation RTK , TCR Signaling , Interferon-gamma Pathway , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Negative Regulation of Hormone Secretion , Carbohydrate Homeostasis , Toll-Like Receptors Cascades , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , VEGFR1 Specific Signals , BCR Signaling , L'effet Warburg
Vus récemment
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