PRKAR2B anticorps

N° du produit ABIN6291856

Détail du produit anti-PRKAR2B anticorps

Antigène: PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAR2B est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein of human PRKAR2B

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Commentaires:

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta, Their expression varies among tissues and is in some cases constitutive and in others inducible

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détails sur PRKAR2B

Antigène: PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))

Autre désignation: PRKAR2B (PRKAR2B Produits)

Synonymes: anticorps MGC83177, anticorps PRKAR2B, anticorps AI451071, anticorps AW061005, anticorps PKARIIbeta, anticorps Pkarb2, anticorps RII(beta), anticorps RATDNA, anticorps PRKAR2, anticorps RII-BETA, anticorps protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog, anticorps protein kinase cAMP-dependent type II regulatory subunit beta, anticorps protein kinase, cAMP-dependent, regulatory, type II, beta, anticorps protein kinase, cAMP dependent regulatory, type II beta, anticorps protein kinase cAMP-dependent type 2 regulatory subunit beta, anticorps prkar2b.S, anticorps PRKAR2B, anticorps prkar2b, anticorps Prkar2b

Sujet: CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

Poids moléculaire: 46.302 kDa

ID gène: 5577

UniProt: P31323

Pathways: Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2