Leptin Receptor anticorps (AA 874-1075)

N° du produit ABIN7367160

Détail du produit anti-Leptin Receptor anticorps

Antigène: Leptin Receptor (LEPR)

Épitope: AA 874-1075

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Leptin Receptor est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Leptin receptor protein (874-1075AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Leptin Receptor

Antigène: Leptin Receptor (LEPR)

Autre désignation: LEPR (LEPR Produits)

Synonymes: anticorps CD295, anticorps LEP-R, anticorps LEPRD, anticorps OB-R, anticorps OBR, anticorps obr, anticorps cd295, anticorps ob-rb, anticorps Fa, anticorps LEPROT, anticorps Leprb, anticorps Modb1, anticorps OB-RGRP, anticorps Obr, anticorps db, anticorps diabetes, anticorps obese-like, anticorps obl, anticorps ObRb, anticorps Ob-R, anticorps Ob-RM, anticorps lepr, anticorps leptin receptor, anticorps leptin receptor S homeolog, anticorps LEPR, anticorps lepr, anticorps Lepr, anticorps lepr.S

Sujet:

Background: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).

Aliases: CD 295 antibody, CD295 antibody, CD295 antigen antibody, Db antibody, Fa antibody, HuB219 antibody, LEP R antibody, LEP-R antibody, LEPR antibody, LEPR_HUMAN antibody, LEPRD antibody, Leptin receptor antibody, Leptin receptor fatty antibody, Leptin receptor gene related protein antibody, Leptin receptor precursor antibody, Leptin receptor precursor antibody, OB R gene related protein antibody, OB receptor antibody, OB-R antibody, OB-RGRP antibody, obl antibody, Obr antibody

UniProt: P48357

Pathways: Signalistation JAK/STAT, AMPK Signaling, Feeding Behaviour