Mre11 anticorps (pSer676) (Cy5.5)

N° du produit ABIN744163

Détail du produit anti-Mre11 anticorps (Cy5.5)

Antigène: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Épitope: pSer676

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Mre11 est conjugé à/à la Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from rat Mre11 around the phosphorylation site of Ser676

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Mre11

Antigène: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Autre désignation: Mre11 (MRE11A Produits)

Synonymes: anticorps wu:faa63d12, anticorps zgc:64018, anticorps Mre11, anticorps Mre11b, anticorps ATLD, anticorps HNGS1, anticorps MRE11, anticorps MRE11B, anticorps MRE11 homolog A, double strand break repair nuclease, anticorps MRE11 homolog, double strand break repair nuclease, anticorps MRE11A homolog A, double strand break repair nuclease, anticorps mre11a, anticorps MRE11, anticorps Mre11a

Sujet:

Synonyms: Mre 11, MRE 11a, MRE 11b, MRE11 homolog 1, MRE11 meiotic recombination 11 homolog A, MRE11a, MRE11b, AT like disease, Ataxia telangiectasia disorder like, Ataxia-telangiectasia disorder-like, ATLD, DNA recombination and repair protein, Double strand break repair protein MRE11A, Double-strand break repair protein MRE11A, endo/exonuclease Mre11. HNGS1, meiotic recombination S. cerevisiae 11 homolog A, meiotic recombination 11 homolog A S. cerevisiae, meiotic recombination 11 homolog A, M mMRE11A.MRE11_RAT

Background: Mre11 is a component of the MRN complex, which plays a critical role in double-strand break repair (DSB), DNA recombination, maintenance of telomere integrity, and meiosis. Mre11 has both single-strand endonuclease and double strand-specific 3'-5' exonuclease activities. Rad50, another component of the MRN complex, is postulated to bind to DNA ends and hold them in close proximity, thus facilitating searches for regions of sequence homology, and also possibly stimulating the activity of DNA ligases and/or restricting Mre11 activity. Mutations in Mre11 may cause breast cancer.

ID gène: 4361

Pathways: Réparation de l'ADN