PTPN1 anticorps (AA 269-435)

N° du produit ABIN967772

Détail du produit anti-PTPN1 anticorps

Antigène: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Épitope: AA 269-435

Reactivité: Humain, Souris, Rat, Chien, Poulet, Grenouille

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PTPN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Chien, Rat (Rattus), Souris, Poulet, Grenouille

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human PTP1B aa. 269-435

Clone: 15-PTP1B

Isotype: IgG2a

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-PTPN1 (ABIN967772)

Rutledge, Whiteheart: "SNAP-23 is a target for calpain cleavage in activated platelets." dans: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37009-15, (2002) (PubMed).

Xu, Arregui, Lilien, Balsamo: "PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site." dans: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49989-97, (2002) (PubMed).

Tao, Malbon, Wang: "Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B." dans: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 39705-12, (2001) (PubMed).

Bharadwaj, Ali, Ovsenek: "Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 In vivo." dans: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8033-41, (2000) (PubMed).

Gaits, Li, Bigay, Ragab, Ragab-Thomas, Chap: "G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid." dans: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 20151-5, (1996) (PubMed).

Détails sur PTPN1

Antigène: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Autre désignation: PTP1B (PTPN1 Produits)

Synonymes: anticorps PTPN1, anticorps PTP1B, anticorps PTP-1B, anticorps PTP-HA2, anticorps Ptp, anticorps ptp1b, anticorps wu:fk54h03, anticorps CPTP1, anticorps protein tyrosine phosphatase, non-receptor type 1, anticorps protein tyrosine phosphatase, non-receptor type 1 L homeolog, anticorps PTPN1, anticorps Ptpn1, anticorps ptpn1, anticorps ptpn1.L

Sujet: PTP1B is a member of the class of enzymes termed protein tyrosine phosphatases (PTPs). This 50 kDa protein contains a conserved phosphatases domain at residues 30-278 and is localized to the cytoplasmic face of the endoplasmic reticulum by its C-terminal 35 residues. Its interactions with other proteins are mediated by proline-rich regions and SH2 compatible sequences. PTP1B is thought to act as a negative regulator in insulin signaling. Insulin stimulation induces its association with the insulin receptor and tyrosine phosphorylation. Its overexpression inhibits proximal and distal insulin signaling events, possibly due to receptor dephosphorylation. Microinjection of PTP1B into Xenopus oocytes blocks insulin-induced maturation. Additional studies demonstrate that PTP1B undergoes cell cycle-dependent and/or stress-induced serine phosphorylation. This suggests further regulatory roles that are not yet defined.

Poids moléculaire: 50 kDa

Pathways: Signalisation TLR, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling