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Human Monoclonal GCLC Primary Antibody pour IF, ELISA - ABIN561050
Hardwick, Fisher, Canet, Lake, Cherrington: Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease. dans Drug metabolism and disposition: the biological fate of chemicals 2010
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Cow (Bovine) Polyclonal GCLC Primary Antibody pour IHC, WB - ABIN2785780
Bardag-Gorce, Oliva, Lin, Li, French, French: Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. dans Experimental and molecular pathology 2011
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Arabidopsis thaliana Polyclonal GCLC Primary Antibody pour IL, WB - ABIN190704
Ghanta, Bhattacharyya, Sinha, Banerjee, Chattopadhyay: Nicotiana tabacum overexpressing γ-ECS exhibits biotic stress tolerance likely through NPR1-dependent salicylic acid-mediated pathway. dans Planta 2011
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Cow (Bovine) Polyclonal GCLC Primary Antibody pour IP, WB - ABIN4313738
Theodoratos, Blackburn, Cappello, Tummala, Dahlstrom, Board: Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase. dans Biochemical pharmacology 2011
Cow (Bovine) Polyclonal GCLC Primary Antibody pour IHC, WB - ABIN2774078
Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. dans International archives of occupational and environmental health 2008
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Microarray analysis revealed that glutamate (Montrer GRIN2A Anticorps) cysteine ligasec overexpression and thus enhanced glutathione production has a broad impact on gene expression that largely affects different processes in young and old flies.
investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels
Neuronal overexpression of GCLc in a long-lived background extended mean and maximum life spans up to 50%, without affecting the rate of oxygen consumption by the flies
The reversibility of the dephosphorylation-dependent activation was indicated by the time-dependent inactivation of the in vitro activated Drosophila GCL, by preincubation with MgATP.
that the longevity effects of GCLc are dependent on dosage and that there are specific tissues (mushroom bodies, motor neurons, and transverse muscle cells) particularly sensitive to the benefits of GCLc overexpression.
GSH biosynthesis in the nucleus is associated with migration of only the GCLc subunit from the cytoplasm into the nucleus, and this migration requires the presence of an intact nuclear localization signal
gamma-GCS has a role in chemo- and radio-resistance of human hepatocellular carcinoma cells
The findings indicate that expression of the transcription factor NRF2 and its effector GCL are both profoundly deregulated in endometriotic lesions towards increased growth and fibrogenetic processes.
Taken together, our findings provide evidence that G9a (Montrer EHMT2 Anticorps) protects head and neck squamous cell carcinomas (HNSCC)cells against chemotherapy by increasing the synthesis of GSH, and imply G9a (Montrer EHMT2 Anticorps) as a promising target for overcoming cisplatin resistance in HNSCC
A panel consisting of IGFBP1 (Montrer IGFBPI Anticorps), KIM1 (Montrer HAVCR1 Anticorps), GCLC and GSTM1 (Montrer GSTM1 Anticorps) genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1 (Montrer FN1 Anticorps), IGFBP3 (Montrer IGFBP3 Anticorps) and KLK1 (Montrer KLK1 Anticorps) could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use.
High GCLC expression is associated with chemotherapy resistance in breast cancer.
Knockdown of CD44 (Montrer CD44 Anticorps) reduced the protein level of xCT (Montrer SLC7A11 Anticorps), a cystine transporter, and increased oxidative stress. However, an increase in GSH was also observed and was associated with enhanced chemoresistance in CD44 (Montrer CD44 Anticorps)-knockdown cells. Increased GSH was mediated by the Nrf2 (Montrer GABPA Anticorps)/AP-1 (Montrer FOSB Anticorps)-induced upregulation of GCLC, a subunit of the enzyme catalyzing GSH synthesis
GCLC polymorphisms correlated with brain GSH and Glu (Montrer DCTN1 Anticorps) levels in psychosis.
NQO1 (Montrer NQO1 Anticorps) and GCLC were both functionally sufficient to autonomously confer a tamoxifen-resistant metabolic phenotype, characterized by i) increased mitochondrial biogenesis, ii) increased ATP production and iii) reduced glutathione levels.
(i) melatonin counteracted UVR-induced alterations in the ATP synthesis and reduced free radical formation; (ii) melatonin induced the translocation of Nrf2 (Montrer GABPA Anticorps) transcription factor from the cytosol into the nucleus resulting in, (iii) melatonin enhanced gene expression of phase-2 antioxidative enzymes including gamma-glutamylcysteine synthetase (gamma-GCS), heme oxygenase-1 (HO-1 (Montrer HMOX1 Anticorps)), and NADPH (Montrer NQO1 Anticorps): quinone dehydrogenase-1 (NQO1 (Montrer NQO1 Anticorps)...
Glutaminolysis is activated in ES2 (Montrer DGCR14 Anticorps) and OVCAR3, though ES2 (Montrer DGCR14 Anticorps) exclusively synthesizes amino acids and GSH. ES2 (Montrer DGCR14 Anticorps) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (Montrer DGCR14 Anticorps) to carboplatin. HNF1beta (Montrer HNF1B Anticorps) regulates the expression of GCLC, but not GCLM (Montrer GCLM Anticorps), and consequently GSH production in ES2 (Montrer DGCR14 Anticorps)
Retinal GCLC was significantly increased in rd10 (Montrer PDE6B Anticorps) mice at P21 (Montrer D4S234E Anticorps) as well as GSSG. Our results suggest alterations in retinal GCLC content and GSH and/or its precursors in these two RP animal models. Regulation of the enzymes related to GSH metabolism and the retinal concentration of glutamate (Montrer GRIN1 Anticorps) may be a possible target to delay especially cone death in Retinitis Pigmentosa
Data show that the catalytic subunit of glutamate cysteine ligase (Gclc)-derived glutathione buffers reactive oxygen species (ROS (Montrer ROS1 Anticorps)), and regulates metabolic reprogramming.
To study the biological effects of low GSH levels, we disrupted its synthesis both at birth by breeding a Gclc loxP mouse with a thy1 (Montrer THY1 Anticorps)-cre mouse and at a later age by breeding with a CaMKII (Montrer CAMK2G Anticorps)-ERT2 (Montrer MAPK3 Anticorps)-Cre (FIGSKO mouse). FIGSKO mice also develop cognitive abnormalities, i.e. learning impairment and nesting behaviors based on passive avoidance, T-Maze, and nesting behavior tests
A floxed Gclc mouse was generated and crossed with a transgenic mouse expressing Cre in the lens to generate the Lens Glutathione Synthesis Knockout mouse in which de novo GSH synthesis was completely abolished in the lens.
Clinically relevant levels of TGF-beta1 (Montrer TGFB1 Anticorps) suppresses GCLC and GCLM (Montrer GCLM Anticorps) expression in mouse lung.
Data show for the first time that GCLC may serve a dual role, as a surrogate marker for cellular redox state as well as malignant potential of melanoma cells.
The impacts of four clinical missense mutations on GCLC enzymatic function in vivo and in vitro, was evaluated.
tBHQ has beneficial effects on reducing hyperglycemia-induced kidney injury, which is associated with the enhanced expression of Nrf2 (Montrer NFE2L2 Anticorps), and its downstream antioxidant HO-1 (Montrer HMOX1 Anticorps) and gamma-GCS (Montrer UGCG Anticorps) in the glomeruli of diabetic mice
In first days of life luminescence measured was in all mice with distinct strain differences indicating NF-kappaB (Montrer NFKB1 Anticorps), superoxide dismutase (Montrer SOD1 Anticorps), gamma-glutamylcysteine synthetase, and antioxidant responsive element activity.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
glutamate--cysteine ligase catalytic subunit
, glutamate-cysteine ligase, catalytic subunit
, gamma-Glutamylcysteine synthetase
, gamma-Glutamylcysteine synthetase catalytic subunit
, gamma-glutamylcysteine ligase
, glutamate cysteine ligase
, glutamate-cysteine ligase
, gamma glutamylcysteine synthetase
, glutamate--cysteine ligase, chloroplastic
, GCS heavy chain
, gamma-glutamylcysteine synthetase
, gamma GCS-HS
, gamma-glutamylcysteine synthetase heavy subunit
, Glutamylcysteine gamma synthetase light chain
, glutamate-cysteine ligase catalytic subunit