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maintenance of the cancer cell state is dependent on recruitment of Mediator and Cohesin through FOXA and master transcription factors
co-expression of PPARgamma (Montrer PPARG Anticorps) and TRAP220 represents a biomarker for good prognosis in colorectal cancer patients
Data suggest that mediator complex subunit 1 (Med1/TRAP220) is a target for checkpoint kinase 2 (Chk2 (Montrer CHEK2 Anticorps))-mediated phosphorylation and may play a role in cellular DNA damage responses by mediating proper induction of gene transcription upon DNA damage.
In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR (Montrer NR3C1 Anticorps)) pathway with the genes MED1, HSPA1L (Montrer HSPA1L Anticorps), GTF2A1 (Montrer GTF2A1 Anticorps) and TAF15 (Montrer TAF15 Anticorps), which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.
modulation of ESR1 (Montrer ESR1 Anticorps)-MED1 interactions by cAMP signaling plays a critical role in human decidualization.
Our data indicate that MED1 serves as a key mediator in ARv567es induced gene expression
Results show that miR-1 (Montrer FSD1 Anticorps) is downregulated in osteosarcoma cells but both of its targets Med1 and Med31 (Montrer MED31 Anticorps) were overexpressed suggesting that MiR-1 (Montrer FSD1 Anticorps) plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 and Med31 (Montrer MED31 Anticorps).
MED1 is required for optimal PRDM16 (Montrer PRDM16 Anticorps)-induced Ucp1 (Montrer UCP1 Anticorps) expression
no association between SCZ and the SNPs of VDR (Montrer CYP27B1 Anticorps), suggesting that VDR (Montrer CYP27B1 Anticorps) is not a major gene for SCZ in Chinese Han population. However, our data indicate a potential involvement of VDR (Montrer CYP27B1 Anticorps) SNPs in the susceptibility of risperidone-treated patients to MetS (Montrer ETV3 Anticorps)
hyperactivated ERK (Montrer EPHB2 Anticorps) and/or AKT (Montrer AKT1 Anticorps) signaling pathways promoted MED1 overexpression in prostate cancer cells.
Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (Montrer MBD4 Anticorps) plays role in enamel formation; Med1 (Montrer MBD4 Anticorps) induces Alpl (Montrer ALPL Anticorps) via stimulation of Notch1 (Montrer NOTCH1 Anticorps) signaling by forming Notch1 (Montrer NOTCH1 Anticorps)-RBP-Jk (Montrer RBPJ Anticorps) complex on Alpl (Montrer ALPL Anticorps) promoter. (Med1 (Montrer MBD4 Anticorps) = mediator complex subunit 1; Alpl (Montrer ALPL Anticorps) = alkaline phosphatase, liver-bone-kidney; Notch1 (Montrer NOTCH1 Anticorps) = Notch gene homolog 1 (Montrer NOTCH1 Anticorps); RBP-Jk (Montrer RBPJ Anticorps) = kappa J region recombining binding protein suppressor of hairless (Montrer RBPJ Anticorps))
MED1 (Montrer MBD4 Anticorps) in macrophages has an antiatherosclerotic role via PPARgamma (Montrer PPARG Anticorps)-regulated transactivation.
Cardiomyocyte-specific ablation of Med1 (Montrer MBD4 Anticorps) causes lethal dilated cardiomyopathy in mice.
Med1 (Montrer MBD4 Anticorps) deletion disrupted cardiac mitochondrial and metabolic gene expression patterns
Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop formation, are dynamically recruited to the IgH locus enhancers.
We conclude that MED1 (Montrer MBD4 Anticorps) regulates the temporal progression of primary spermatocytes through meiosis, with its absence resulting in abbreviated pre-leptotene, leptotene, and zygotene stages, and a prolonged pachytene stage.
These results demonstrate that Med1 (Montrer MBD4 Anticorps) is a master regulator in adult stem cells to govern epithelial cell fate
The novel function of MED1 (Montrer MBD4 Anticorps) in keratinocytes.
PRDM16 (Montrer PRDM16 Anticorps) deficiency in BAT (Montrer BAAT Anticorps) reduces MED1 (Montrer MBD4 Anticorps) binding at PRDM16 (Montrer PRDM16 Anticorps) target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes
Collectively, these observations strongly suggest that MED1 (Montrer MBD4 Anticorps) has an important affect on mitochondrial function.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.
, PPAR binding protein
, PPAR-binding protein
, PPARG binding protein
, TR-interacting protein 2
, activator-recruited cofactor 205 kDa component
, mediator of RNA polymerase II transcription subunit 1
, p53 regulatory protein RB18A
, peroxisome proliferator-activated receptor-binding protein
, thyroid hormone receptor-associated protein complex 220 kDa component
, thyroid hormone receptor-associated protein complex component TRAP220
, thyroid receptor interacting protein 2
, thyroid receptor-interacting protein 2
, vitamin D receptor-interacting protein 230 kD
, vitamin D receptor-interacting protein complex component DRIP205
, mediator complex subunit 1
, peroxisome proliferator-activated receptor binding protein
, membrane component, chromosome 17, surface marker 2
, Ppar binding protein
, peroxisome proliferator activated receptor binding protein