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anti-Human Integrin beta 2 Anticorps:
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody pour FACS, Func - ABIN457404
Abraham, Miller: Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. dans Journal of immunology (Baltimore, Md. : 1950) 2001
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody pour FACS, Func - ABIN457348
Avni, Pur, Yefenof, Baniyash: Complement receptor 3 of macrophages is associated with galectin-1-like protein. dans Journal of immunology (Baltimore, Md. : 1950) 1998
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody pour FACS, Func - ABIN457430
Sakurai, Taguchi, Anand, Ambati, Gragoudas, Miller, Adamis, Ambati: Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. dans Investigative ophthalmology & visual science 2003
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody pour BR, IHC (f) - ABIN2689033
Driessens, van Hulten, Zuurbier, La Rivière, Roos: Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. dans Journal of leukocyte biology 1997
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Human Polyclonal Integrin beta 2 Primary Antibody pour BR, FACS - ABIN5012937
van Grevenstein, Hofland, van Rossen, van Koetsveld, Jeekel, van Eijck: Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. dans Digestive diseases and sciences 2007
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody pour BR, Func - ABIN1176975
Isobe, Yagita, Okumura, Ihara: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. dans Science (New York, N.Y.) 1992
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Human Monoclonal Integrin beta 2 Primary Antibody pour WB - ABIN1882257
Chen, Xie, Nishida, Li, Walz, Springer: Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. dans Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Monoclonal Integrin beta 2 Primary Antibody pour FACS, Func - ABIN94005
Nakayama, Yoshizaki, Prinetti, Sonnino, Mauri, Takamori, Ogawa, Iwabuchi: Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. dans Journal of leukocyte biology 2008
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Human Monoclonal Integrin beta 2 Primary Antibody pour FACS, Func - ABIN94007
Sewald, Gebert-Vogl, Prassl, Barwig, Weiss, Fabbri, Osicka, Schiemann, Busch, Semmrich, Holzmann, Sebo, Haas: Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. dans Cell host & microbe 2008
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Human Monoclonal Integrin beta 2 Primary Antibody pour FACS, Func - ABIN94008
Morova, Osicka, Masin, Sebo: RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides. dans Proceedings of the National Academy of Sciences of the United States of America 2008
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LncRNA ITGB2-AS1 (Montrer PTGDR Anticorps) could promote the migration and invasion of breast cancer cells by up-regulating ITGB2.
Data show that integrin alphaLbeta2 (LFA-1) is oriented relative to actin retrograde flow.
Overexpression of ITGB2 was not correlated with ITGB2 promoter hypomethylation in systemic sclerosis.
actin engagement produces tension within the beta2 subunit to induce and stabilize an active integrin conformational state and that this requires intact talin and kindlin motifs.
on tumour-infiltrating T-lymphocytes, galectin prevents the formation of a functional secretory synapse by preventing optimal LFA-1 (Montrer ITGAL Anticorps) triggering
exploration of the underlying mechanism demonstrated that ICAM3 (Montrer ICAM3 Anticorps) not only binds to LFA-1 (Montrer ITGAL Anticorps) with its extracellular domain and structure protein ERM (Montrer ETV5 Anticorps) but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis).
vesicle-associated RhoB is a regulator of the Rab11 (Montrer RAB11A Anticorps)-mediated recycling of LFA-1 (Montrer ITGAL Anticorps) to the cell surface, an event that is necessary for T lymphocyte motility.
The ITGB2 variant rs2230531 was examined in an independent cohort of Tasmanian patients with hematologic malignancies (HM) to see if its presence correlated with chronic lymphocytic leukemia. The variant was found in several lymphoid and myeloid HMs (Montrer CTSC Anticorps), so if contributes to the risk of HM, it does so broadly across HM subtypes in this population.
Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a (Montrer ITGA1 Anticorps)/CD18) activation and binding with soluble/immobilized ICAM1 (Montrer ICAM1 Anticorps) (intercellular cell adhesion molecule 1 (Montrer CADM1 Anticorps)).
an integrated strategy of whole genome and transcriptome analysis enabled identification of LB-ITGB2-1 as HLA-B*15:01-restricted MiHAs encoded by an alternative transcript. The alternative ITGB2 transcript was shown to be expressed in leukemic cells of different origins.
CD18(-/-) leukocytes extravasated later than WT leukocytes. However, once extravasated, CD18(-/-) leukocytes transmigrated more rapidly than their WT counterparts. These results suggest that, although CD18 facilitates efficient extravasation, outside of the vessel CD18 interaction with the extracellular matrix, it reduced transmigration velocity.
A modulatory role for the tumor beta2 subunit of the LFA-1 (Montrer ITGAL Anticorps) integrin in the metastatic progression of colorectal cancer to the liver by impaired activation of liver endothelium.
Data show CD18 is selectively required for T helper 2, but not T helper 1, homing and has a minimal influence on T-effector development.
Adhesive properties of the leukocyte integrin Mac-1 (Montrer ITGAM Anticorps) are not required for macrophage accumulation in adipose tissue. Instead, Mac-1 (Montrer ITGAM Anticorps) modulates inflammatory gene expression in macrophages.
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
An intracellular pool of LFA-1 (Montrer ITGAL Anticorps) in naive CD8 (Montrer CD8A Anticorps)(+) T cells plays a key role in T cell activation and differentiation.
Extracellular ISG15 (Montrer ISG15 Anticorps) signals cytokine secretion through the LFA-1 (Montrer ITGAL Anticorps) integrin receptor (CD11a (Montrer ITGAL Anticorps)/CD18) in natural killer cells.
CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (Montrer CA5A Anticorps))1in membrane organization and beta2 integrin Lfa1 (Montrer ITGAL Anticorps) function in primary CD8 (Montrer CD8A Anticorps) T cells.
Coro1A (Montrer CORO1A Anticorps) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (Montrer SELL Anticorps) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (Montrer CA2 Anticorps)+]i, diminished annexin V (Montrer ANXA5 Anticorps) expression on the cell surface, and decreased caspase 3 (Montrer CASP3 Anticorps) activity in lysates
The I-EGF (Montrer EGF Anticorps)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (Montrer ORM1 Anticorps) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (Montrer POLG Anticorps) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
CR3 (Montrer ITGAM Anticorps) plays a cardinal (Montrer CARD8 Anticorps) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (Montrer ZP3 Anticorps) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (Montrer IRF6 Anticorps) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
Integrin CD11c (Montrer ITGAX Anticorps)/CD18 alpha-chain (Montrer FCGRT Anticorps) phosphorylation is functionally important.
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, complement receptor C3 beta-subunit
, complement receptor C3 subunit beta
, integrin beta chain, beta 2
, integrin beta-2
, leukocyte cell adhesion molecule CD18
, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
, Mac-1 beta
, lymphocyte function associated antigen 1
, macrophage antigen-1 beta
, CD18 subunit
, Leu-CAM receptor
, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
, integrin beta 2 subunit
, CD18 leukocyte adhesion molecule
, antigen CD18
, integrin beta-2 chain
, integrin beta 2
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
, macrophage antigen 1 (mac-1) beta subunit)
, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, Complement receptor C3 subunit beta
, Integrin beta-2
, integrin beta-2 subunit
, integrin subunit beta 2 S homeolog
, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)