Flightless I Homolog (Drosophila) (FLII) Kits ELISA

FLII encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain FLII FLII 2314 Q13045
Anti-Souris FLII FLII 14248 Q9JJ28
Anti-Rat FLII FLII 287375  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 29.2 pg/mL 78.12 pg/mL - 5000 pg/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$736.84
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Plus Kits ELISA pour Flightless I Homolog (Drosophila) partenaires d'interaction

Human Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.

  2. Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS (Montrer EWSR1 Kits ELISA)/FLI activating response elements in vivo and reveal an unexpected role for the EWS (Montrer EWSR1 Kits ELISA) portion of the EWS (Montrer EWSR1 Kits ELISA)/FLI fusion in binding to sweet-spot GGAA-microsatellites.

  3. FLII is a component of the ChREBP transcriptional complex and negatively regulates ChREBP function in cancer cells.

  4. Demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients.

  5. FLII is associated with SENP3 and the MLL1/2 complex and FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus.

  6. Flightless-I (Drosophila) homolog (FLII) activates TGFbeta1 (Montrer TGFB1 Kits ELISA)-mediated expression of COL1A2 (Montrer COL1A2 Kits ELISA) gene.

  7. Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.

  8. FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies.

  9. These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators.

  10. Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma.

Mouse (Murine) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Fluorescence resonance energy transfer experiments showed that FliI-NMMIIA interactions require Ca(2 (Montrer CA2 Kits ELISA)+) influx. We conclude that Ca(2 (Montrer CA2 Kits ELISA)+) influx through the TRPV4 (Montrer TRPV4 Kits ELISA) channel regulates FliI-NMMIIA interaction, which in turn enables generation of the cell extensions essential for collagen remodeling

  2. Flii genetic expression is enhances tissue regeneration, after claw amputation.

  3. Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.

  4. P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein.

  5. Genes downstream from Flii, including TGF-beta1 (Montrer TGFB1 Kits ELISA) and TGF-beta3 (Montrer TGFB3 Kits ELISA), showed significantly altered expression confirming a functional effect of the Rhodamine-Flii small interfering RNA on gene expression

  6. FliI interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling in fibroblasts.

  7. FLII functions in PPARgamma (Montrer PPARG Kits ELISA) activation as a molecular switch to repress transcriptional activity by interrupting formation of the PPARgamma (Montrer PPARG Kits ELISA)/RXRalpha (Montrer RXRA Kits ELISA) complex.

  8. LRRFIP2 inhibits NLRP3 (Montrer NLRP3 Kits ELISA) inflammasome activation by recruiting the caspase-1 (Montrer CASP1 Kits ELISA) inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 (Montrer NLRP3 Kits ELISA) inflammasome.

  9. increasing the level of Flii in diabetic mouse wounds led to increased TLR4 (Montrer TLR4 Kits ELISA) and NF- kappa B (Montrer NFKB1 Kits ELISA) production. Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4 (Montrer TLR4 Kits ELISA)

  10. Using a mouse model of epidermolysis bullosa acquisita, the effect of "mopping up" Flii using Flii-neutralizing antibodies before, during, and after blister formation was determined.

Cow (Bovine) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. These findings strongly demonstrate that the three single nucleotide polymorphisms of FLII gene could be utilized as molecular markers for future assisted selection in cattle breeding program.

Zebrafish Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Embryos defective in flightless I homolog (flii), which encodes for an actin-regulating protein, exhibit normal coilings at 24 hours post fertilization (hpf) that is followed by significantly slower burst swimming at 48 hpf.

Caenorhabditis elegans (C. elegans) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.

  2. FLI-1 controls germ line morphogenesis and rachis organization

Flightless I Homolog (Drosophila) (FLII) profil antigène

Antigen Summary

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Gene names and symbols associated with FLII

  • FLII, actin remodeling protein (FLII) anticorps
  • flightless I actin binding protein (Flii) anticorps
  • FLII, actin remodeling protein (Flii) anticorps
  • flightless I actin binding protein (flii) anticorps
  • protein flightless-1 homolog (LOC585336) anticorps
  • FLII, actin remodeling protein (flii) anticorps
  • protein flightless-1 homolog (LOC100640615) anticorps
  • FLII, actin remodeling protein S homeolog (flii.S) anticorps
  • Protein flightless-1 homolog (fli-1) anticorps
  • 3632430F08Rik anticorps
  • DKFZp459O043 anticorps
  • FLI anticorps
  • Fli1 anticorps
  • flightless anticorps
  • Fliih anticorps
  • FLIL anticorps
  • im:7141769 anticorps

Protein level used designations for FLII

protein flightless-1 homolog , flightless I homolog (Drosophila) , flightless-I homolog , flightless I homolog

GENE ID SPECIES
2314 Homo sapiens
14248 Mus musculus
287375 Rattus norvegicus
416515 Gallus gallus
454486 Pan troglodytes
479521 Canis lupus familiaris
514446 Bos taurus
560281 Danio rerio
585336 Strongylocentrotus purpuratus
700471 Macaca mulatta
100051793 Equus caballus
100173989 Pongo abelii
100398338 Callithrix jacchus
100475330 Ailuropoda melanoleuca
100543687 Meleagris gallopavo
100553018 Anolis carolinensis
100600354 Nomascus leucogenys
100619473 Monodelphis domestica
100640615 Amphimedon queenslandica
444748 Xenopus laevis
176215 Caenorhabditis elegans
100728597 Cavia porcellus
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