JNK anticorps (AA 151-250) (Alexa Fluor 594)

N° du produit ABIN2803473

Détail du produit anti-JNK anticorps (Alexa Fluor 594)

Antigène: JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))

Épitope: AA 151-250

Reactivité: Humain, Souris, Rat, Poulet, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JNK est conjugé à/à la Alexa Fluor 594

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Poulet, Humain, Souris, Porc, Rat

Homologie: Dog,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse JNK1/2/3

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur JNK

Antigène: JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))

Autre désignation: JNK1+2+3 (MAPK8 Produits)

Synonymes: anticorps JNK, anticorps JNK-46, anticorps JNK1, anticorps JNK1A2, anticorps JNK21B1/2, anticorps PRKM8, anticorps SAPK1, anticorps SAPK1c, anticorps AI849689, anticorps Prkm8, anticorps BSK, anticorps BSK/DJNK, anticorps Bsk, anticorps CG5680, anticorps D-JNK, anticorps D-junk, anticorps DBSK/JNK, anticorps DJNK, anticorps DJNK/bsk, anticorps Dmel\\CG5680, anticorps JNK/SAPK, anticorps Jnk, anticorps Junk, anticorps SAPKa, anticorps c-Jun, anticorps dJNK, anticorps jnk, anticorps T10F20.15, anticorps jnk1, anticorps sapk1, anticorps mapk8, anticorps zgc:112379, anticorps JNKb, anticorps mapk8b, anticorps mitogen-activated protein kinase 8, anticorps Stress-activated protein kinase jnk-1, anticorps basket, anticorps Protein kinase superfamily protein, anticorps mitogen-activated protein kinase 8 L homeolog, anticorps mitogen-activated protein kinase 8b, anticorps mitogen-activated protein kinase 8B-like, anticorps MAPK8, anticorps jnk-1, anticorps Mapk8, anticorps bsk, anticorps ATMPK8, anticorps mapk8.L, anticorps mapk8b, anticorps LOC109094263

Sujet:

Synonyms: JNK3, Serk2, JNK3B1, JNK3B2, p493F12, p54bSAPK, SAPK(beta), C238H4Rik, JNK, JNK1, Prkm8, SAPK1, AI849689, JNK2, Prkm9, AI85183, p54aSAPK, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, MAP kinase p49 3F12, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, Mapk1, Prkm1

Background: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.

UniProt: Q61831

Pathways: Signalisation MAPK, Signalisation WNT, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteins