NF-kB p65 anticorps (Ser536)
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- Antigène Voir toutes NF-kB p65 (NFkBP65) Anticorps
- NF-kB p65 (NFkBP65) (Nuclear Factor-kB p65 (NFkBP65))
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Épitope
- Ser536
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NF-kB p65 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects the p65 (RelA) subunit of nuclear factor kappa-B (NFkappaB) when phosphorylated at serine 536.
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Purified
- Immunogène
- Synthetic peptide corresponding to residues surrounding serine 536 of Human NFkB p65 protein.
- Isotype
- IgG
- Top Product
- Discover our top product NFkBP65 Anticorps primaire
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- Indications d'application
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Western Blot: 1: 100 - 1: 1000, detects a band of approximately 65 kDa in the appropriate celllysate. Immunohistochemistry on paraffin sections: 1: 50 - 1: 250. ELISA: 1: 500 - 1: 3000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- NF-kB p65 (NFkBP65) (Nuclear Factor-kB p65 (NFkBP65))
- Autre désignation
- RELA / NF-kB p65 (NFkBP65 Produits)
- Synonymes
- anticorps C-Rel, anticorps NFKB3, anticorps p65, anticorps NFkB, anticorps c-rel, anticorps zgc:100833, anticorps Xrel2, anticorps Xrel3, anticorps rel, anticorps rel-A, anticorps rel2, anticorps rel3, anticorps v-rel, anticorps xrel, anticorps REL proto-oncogene, NF-kB subunit, anticorps RELA proto-oncogene, NF-kB subunit, anticorps v-rel reticuloendotheliosis viral oncogene homolog A (avian), anticorps v-rel avian reticuloendotheliosis viral oncogene homolog, anticorps v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog, anticorps REL, anticorps RELA, anticorps Rela, anticorps Rel, anticorps rel, anticorps rel.L
- Sujet
- NFkappaB is a heterodimeric DNA binding protein which was originally identified consisting of p65 and p50 (NF?B1) subunits. Research has led to the discovery of other subunits, including p52 (NFkappaB2), cRel, and RelB. NFkappaB is ubiquitously expressed, and functions as a second messenger which upon activation leads to the transcription of a number of genes. NFkappaB is activated by a number of agents, including pro-inflammatory cytokines and bacterial lipopolysaccharide, and is essential for the maturation of T cells and regulation of their survival and activation. Phosphorylation of serine 536 contributes to NFkappaB transactivation and increases p65 transcription activity.Synonyms: NF kappa B p65, NFKB3, NFkB p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Rel A, Transcription factor p65
- ID gène
- 5970
- NCBI Accession
- NP_001138610
- UniProt
- Q04206
- Pathways
- Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades, S100 Proteins
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