TRKA anticorps (pSer791)
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- Antigène Voir toutes TRKA (NTRK1) Anticorps
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
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Épitope
- pSer791
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TRKA est non-conjugé
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Application
- Immunofluorescence (IF)
- Specificité
- Antibody AP09480PU detects endogenous levels of TrkA only when phosphorylated at Tyrosine 791.
- Purification
- Immunoaffinity Chromatography using epitope-specific phosphopeptide.
- Immunogène
- The antiserum was produced against synthesized phosphopeptide derived from human TrkA around the phosphorylation site of tyrosine791 (P-V-Yp-L-D).
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- Discover our top product NTRK1 Anticorps primaire
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- Indications d'application
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Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody (in aliquots) at-20 °C.
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- Antigène
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- Autre désignation
- TrkA (NTRK1 Produits)
- Synonymes
- anticorps MTC, anticorps TRK, anticorps TRK1, anticorps TRKA, anticorps Trk-A, anticorps p140-TrkA, anticorps CDHF12, anticorps CDHR16, anticorps HSCR1, anticorps MEN2A, anticorps MEN2B, anticorps MTC1, anticorps PTC, anticorps RET-ELE1, anticorps RET51, anticorps Trk, anticorps C80751, anticorps Tkr, anticorps TrkA, anticorps trk, anticorps trka, anticorps CTRKA, anticorps trkA, anticorps neurotrophic receptor tyrosine kinase 1, anticorps ret proto-oncogene, anticorps neurotrophic tyrosine kinase, receptor, type 1, anticorps NTRK1, anticorps RET, anticorps Ntrk1, anticorps ntrk1
- Sujet
- The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
- ID gène
- 4914
- NCBI Accession
- NP_001007793
- UniProt
- P04629
- Pathways
- Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process
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