PTPN11 anticorps (C-Term)

N° du produit ABIN500708

Détail du produit anti-PTPN11 anticorps

Antigène: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN11 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects PTPN11 / SHP-2 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: SHP2 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human SHP2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur PTPN11

Antigène: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Autre désignation: PTPN11 / PTP2C (PTPN11 Produits)

Synonymes: anticorps BPTP3, anticorps CFC, anticorps NS1, anticorps PTP-1D, anticorps PTP2C, anticorps SH-PTP2, anticorps SH-PTP3, anticorps SHP2, anticorps 2700084A17Rik, anticorps AW536184, anticorps PTP1D, anticorps SAP-2, anticorps SHP-2, anticorps Shp2, anticorps Syp, anticorps SYP, anticorps bptp3, anticorps cfc, anticorps ns1, anticorps ptp-2, anticorps ptp2c, anticorps ptpn11, anticorps ptpn11-a, anticorps ptpn11-b, anticorps shp-2, anticorps shp2, anticorps fa14b09, anticorps wu:fa14b09, anticorps wu:fi24f03, anticorps zgc:55388, anticorps zgc:63553, anticorps protein tyrosine phosphatase, non-receptor type 11, anticorps protein tyrosine phosphatase, non-receptor type 11 S homeolog, anticorps protein tyrosine phosphatase, non-receptor type 11, a, anticorps protein tyrosine phosphatase, non-receptor type 11, b, anticorps PTPN11, anticorps Ptpn11, anticorps ptpn11.S, anticorps ptpn11a, anticorps ptpn11b

Classe de substances: Viral Protein

Sujet: Src homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.Synonyms: PTP-1D, PTP-2C, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, SH-PTP2, SH-PTP3, SHP-2, SHPTP2, Shp2, Tyrosine-protein phosphatase non-receptor type 11

ID gène: 5781

NCBI Accession: NP_002825

UniProt: Q06124

Pathways: Signalistation JAK/STAT, Signalisation RTK, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, L'effet Warburg