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PTPN11 anticorps (AA 1-460)
PTPN11
Reactivité: Humain
WB, IF, IP
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN6146440
Détail du produit anti-PTPN11 anticorps
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Antigène
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PTPN11
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
Épitope
Tous les épitopes à travers PTPN11 Anticorps.
AA 1-460
Reactivité
Toutes les réactivités sur PTPN11 Anticorps
Humain
Hôte
Toutes les hôtes sur PTPN11 Anticorps
Lapin
Clonalité
Toutes les clonalités sur PTPN11 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers PTPN11 Anticorps
Cet anticorp PTPN11 est non-conjugé
Application
Tous les applications à travers PTPN11 Anticorps.
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
Séquence
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIM DAGPVVVHCS
Réactivité croisée
Humain, Souris, Rat
Attributs du produit
Polyclonal Antibodies
Immunogène
Recombinant fusion protein containing a sequence corresponding to amino acids 1-460 of human SHP2 (NP_002825.3).
Isotype
IgG
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Alternatives
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Information d'application
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Indications d'application
WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Store at -20°C. Avoid freeze / thaw cycles.
Détails sur PTPN11
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Antigène
PTPN11
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
Autre désignation
PTPN11 (PTPN11 Produits )
Synonymes
anticorps BPTP3, anticorps CFC, anticorps NS1, anticorps PTP-1D, anticorps PTP2C, anticorps SH-PTP2, anticorps SH-PTP3, anticorps SHP2, anticorps 2700084A17Rik, anticorps AW536184, anticorps PTP1D, anticorps SAP-2, anticorps SHP-2, anticorps Shp2, anticorps Syp, anticorps SYP, anticorps bptp3, anticorps cfc, anticorps ns1, anticorps ptp-2, anticorps ptp2c, anticorps ptpn11, anticorps ptpn11-a, anticorps ptpn11-b, anticorps shp-2, anticorps shp2, anticorps fa14b09, anticorps wu:fa14b09, anticorps wu:fi24f03, anticorps zgc:55388, anticorps zgc:63553, anticorps protein tyrosine phosphatase, non-receptor type 11, anticorps protein tyrosine phosphatase, non-receptor type 11 S homeolog, anticorps protein tyrosine phosphatase, non-receptor type 11, a, anticorps protein tyrosine phosphatase, non-receptor type 11, b, anticorps PTPN11, anticorps Ptpn11, anticorps ptpn11.S, anticorps ptpn11a, anticorps ptpn11b
Classe de substances
Viral Protein
Sujet
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.,BPTP3,CFC,JMML,METCDS,NS1,PTP-1D,PTP2C,SH-PTP2,SH-PTP3,SHP2,PTPN11,Signal Transduction,Kinase,Tyrosine kinases,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,IL-6 Receptor Signaling Pathway,Neuroscience,PTPN11
Poids moléculaire
52 kDa/68 kDa
ID gène
5781
UniProt
Q06124
Pathways
Signalistation JAK/STAT , Signalisation RTK , TCR Signaling , Interferon-gamma Pathway , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Negative Regulation of Hormone Secretion , Carbohydrate Homeostasis , Toll-Like Receptors Cascades , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , VEGFR1 Specific Signals , BCR Signaling , L'effet Warburg
Vus récemment
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