PKC zeta anticorps (pThr560)

N° du produit ABIN7138399

Détail du produit anti-PKC zeta anticorps

Antigène: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Épitope: pThr560

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKC zeta est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phospho rylation site of threonine560(Q-L-T(p)-P-D) derived from Human PKC zeta .

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PKC zeta

Antigène: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Autre désignation: PRKCZ (PRKCZ Produits)

Synonymes: anticorps TPKC, anticorps PKCzeta, anticorps prkcz-A, anticorps pkc-zeta, anticorps PRKCZ, anticorps pkc2, anticorps PKC-ZETA, anticorps PKC2, anticorps AI098070, anticorps C80388, anticorps Pkcz, anticorps R74924, anticorps aPKCzeta, anticorps zetaPKC, anticorps 14-3-3-zetaisoform, anticorps r14-3-3, anticorps pkcz, anticorps si:ch211-150o23.4, anticorps protein kinase C zeta L homeolog, anticorps protein kinase C zeta, anticorps protein kinase C, zeta, anticorps prkcz.L, anticorps PRKCZ, anticorps prkcz, anticorps Prkcz

Sujet:

Background:

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Nakayama M, et al. (2013)Nat Cell Biol 15, 249-60. Mayanglambam A, Bhavanasi D, Vijayan KV, Kunapuli SP (2011)Biochem Pharmacol 82, 505-13. Dettori R, et al. (2009)J Biol Chem 284, 30318-27.

Aliases: 14-3-3-zetaisoform antibody, AI098070 antibody, aPKCzeta antibody, C80388 antibody, EC 2.7.11.13 antibody, KPCZ_HUMAN antibody, nPKC zeta antibody, nPKC-zeta antibody, OTTHUMP00000001368 antibody, OTTHUMP00000044160 antibody, PKC 2 antibody, PKC ZETA antibody, PKC2 antibody, Pkcz antibody, PKCZETA antibody, PKM-zeta, included antibody, PRKCZ antibody, Protein kinase C zeta antibody, Protein kinase C zeta form antibody, Protein kinase C zeta type antibody, r14-3-3 antibody, R74924 antibody, zetaPKC antibody

UniProt: Q05513

Pathways: Signalisation NF-kappaB, Signalisation RTK, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling