CHEK1
Reactivité: Humain, Souris, Rat
IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:500~1:1000 IHC: 1:50~1:100.
Restrictions
For Research Use only
Format
Liquid
Concentration
100ug/100ul.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Zhang, Otterness, Chiang, Xie, Liu, Mercurio, Abraham: "Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway." dans: Molecular cell, Vol. 19, Issue 5, pp. 607-18, (2005) (PubMed).
Rocha, Garrett, Campbell, Schumm, Perkins: "Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor." dans: The EMBO journal, Vol. 24, Issue 6, pp. 1157-69, (2005) (PubMed).
Clarke, Clarke: "DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system." dans: The Biochemical journal, Vol. 388, Issue Pt 2, pp. 705-12, (2005) (PubMed).
Yu, Chen: "DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains." dans: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9478-86, (2004) (PubMed).