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Human Polyclonal Ube2t Primary Antibody pour ELISA, WB - ABIN1003408
Sancho, Vilá, Sánchez-Pulido, Lozano, Paciucci, Nadal, Fox, Harvey, Bercovich, Loukili, Ciechanover, Lin, Sanz, Estivill, Valencia, Thomson: Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. dans Molecular and cellular biology 1998
Show all 4 Pubmed References
Human Polyclonal Ube2t Primary Antibody pour ELISA, WB - ABIN546987
Machida, Machida, Chen, Gurtan, Kupfer, DAndrea, Dutta: UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. dans Molecular cell 2006
Human Monoclonal Ube2t Primary Antibody pour IP, ELISA - ABIN565405
Ramaekers, van den Beucken, Meng, Kassam, Thoms, Bristow, Wouters: Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T. dans Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011
Results show that UBE2T expression was increased in gastric tumors. Its suppression altered the expression of epithelial-mesenchymal transition factors and inhibited growth and colony formation, increased G2/M phase cell cycle arrest, and promoted apoptosis in gastric cancer cells. These findings provide evidence that UBE2T plays a critical role in gastric cancer.
High UBE2T expression is associated with nasopharyngeal carcinoma.
Collectively, our findings suggest UBE2T serves as a promising prognostic factor for HCC and functions as an oncogene. The newly identified miR-543/UBE2T/p53 axis may represent a new potential therapeutic target for HCC intervention.
report the identification of a new allosteric pocket on Ube2T through a fragment screening using biophysical methods. Several fragments binding to this site inhibit ubiquitin conjugation in vitro
Results showed that UBE2T was overexpressed in osteosarcoma tissues and cell lines. Moreover, UBE2T knockdown inhibited osteosarcoma cell proliferation, migration, and invasion.
UBE2T plays an important role in the tumorigenesis of gastric cancer and could act as a potential independent prognostic factor for cancer therapy.
Identify critical roles of UBE2T in prostate cancer development and progression.
we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer susceptibility gene.
UBE2T is the primary E2 of the FA pathway required for FANCD2 and FANCI activation.
Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia
hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway
UBE2T is the ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway.
UBE2T was significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype.
This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination.
Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair.
Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex.
Overexpression of UBE2T in NIH3T3 cells significantly promoted colony formation in mouse cell cultures.
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006
HSPC150 protein similar to ubiquitin-conjugating enzyme
, cell proliferation-inducing gene 50 protein
, ubiquitin carrier protein T
, ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme E2 T
, ubiquitin-protein ligase T
, ubiquitin-conjugating enzyme E2T (putative)
, ubiquitin-conjugating enzyme E2T
, similar to Ubiquitin-conjugating enzyme E2 T (Ubiquitin-protein ligase T) (Ubiquitin carrier protein T)