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GSK3 alpha anticorps (truncated)
GSK3a
Reactivité: Humain
WB, ELISA
Hôte: Souris
Monoclonal
6G12C2
unconjugated
N° du produit ABIN2464060
Détail du produit anti-GSK3 alpha anticorps
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Antigène
Voir toutes GSK3 alpha (GSK3a) Anticorps
GSK3 alpha (GSK3a)
(Glycogen Synthase Kinase 3 alpha (GSK3a))
Épitope
Tous les épitopes à travers GSK3 alpha Anticorps.
truncated
Reactivité
Toutes les réactivités sur GSK3 alpha Anticorps
Humain
Hôte
Toutes les hôtes sur GSK3 alpha Anticorps
Souris
Clonalité
Toutes les clonalités sur GSK3 alpha Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers GSK3 alpha Anticorps
Cet anticorp GSK3 alpha est non-conjugé
Application
Tous les applications à travers GSK3 alpha Anticorps.
Western Blotting (WB), ELISA
Immunogène
Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3).
Clone
6G12C2
Isotype
IgG1
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Discover our top product GSK3a Anticorps primaire
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Information d'application
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Indications d'application
Western Blot:1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Stockage
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Buffer
Ascitic fluid containing 0.03 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Stock
-20 °C
Stockage commentaire
GSK3 alpha monoclonal antibody can be stored at -20 °C, stable for one year.
Détails sur GSK3 alpha
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Antigène
GSK3 alpha (GSK3a)
(Glycogen Synthase Kinase 3 alpha (GSK3a))
Autre désignation
GSK3alpha (GSK3a Produits )
Synonymes
anticorps 2700086H06Rik, anticorps GSK3A, anticorps GSK-3[a], anticorps GSK-3[b], anticorps GSK3, anticorps gsk3a, anticorps xgsk3, anticorps glycogen synthase kinase 3 alpha, anticorps glycogen synthase kinase 3 alpha b, anticorps glycogen synthase kinase 3 alpha S homeolog, anticorps GSK3A, anticorps Gsk3a, anticorps gsk3a, anticorps gsk3ab, anticorps gsk3a.S, anticorps Bm1_31380
Sujet
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily?GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97 % sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
ID gène
2931
UniProt
P49840
Pathways
Signalisation PI3K-Akt , Signalisation WNT , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , cAMP Metabolic Process , Cellular Glucan Metabolic Process , Regulation of Muscle Cell Differentiation , Regulation of G-Protein Coupled Receptor Protein Signaling , ER-Nucleus Signaling , Regulation of Carbohydrate Metabolic Process , BCR Signaling , L'effet Warburg
Vus récemment
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