GSK3 alpha anticorps (N-Term) (Sepharose)

N° du produit ABIN375564

Détail du produit anti-GSK3 alpha anticorps (Sepharose)

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GSK3 alpha est conjugé à/à la Sepharose

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificité: Human/Mouse GSK-3α

Attributs du produit: Mouse Anti-GSK-3a-SEPH

Purification: Purified

Immunogène: Recombinant N-terminal GSK-3alpha

Clone: SBGSK3a4

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: WB - Quality tested , IP - Quality tested
• Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL HRP conjugate 1:2,000 - 1:5,000 Immunoprecipitation Purified (UNLB) antibody 5 g SEPH conjugate 40 L

Restrictions: For Research Use only

Stockage

Buffer: 50 tests in 2.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine- containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur GSK3 alpha

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Autre désignation: GSK-3a (GSK3a Produits)

Synonymes: anticorps 2700086H06Rik, anticorps GSK3A, anticorps GSK-3[a], anticorps GSK-3[b], anticorps GSK3, anticorps gsk3a, anticorps xgsk3, anticorps glycogen synthase kinase 3 alpha, anticorps glycogen synthase kinase 3 alpha b, anticorps glycogen synthase kinase 3 alpha S homeolog, anticorps GSK3A, anticorps Gsk3a, anticorps gsk3a, anticorps gsk3ab, anticorps gsk3a.S, anticorps Bm1_31380

Sujet: Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 α and GSK-3β. The two isoforms share 97 % sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Pathways: Signalisation PI3K-Akt, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, L'effet Warburg