GSK3 alpha anticorps (N-Term)

N° du produit ABIN375590

Détail du produit anti-GSK3 alpha anticorps

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GSK3 alpha est non-conjugé

Application: Western Blotting (WB)

Specificité: Human/Mouse GSK-3α

Attributs du produit: Mouse Anti-GSK-3a-UNLB

Purification: Purified

Immunogène: Recombinant N-terminal GSK-3alpha

Clone: SBGSK3a1

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: WB - Quality tested
• Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL HRP conjugate 1:1,000 - 1:5,000

Volume d'échantillon: 0,2 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur GSK3 alpha

Antigène: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Autre désignation: GSK-3a (GSK3a Produits)

Synonymes: anticorps 2700086H06Rik, anticorps GSK3A, anticorps GSK-3[a], anticorps GSK-3[b], anticorps GSK3, anticorps gsk3a, anticorps xgsk3, anticorps glycogen synthase kinase 3 alpha, anticorps glycogen synthase kinase 3 alpha b, anticorps glycogen synthase kinase 3 alpha S homeolog, anticorps GSK3A, anticorps Gsk3a, anticorps gsk3a, anticorps gsk3ab, anticorps gsk3a.S, anticorps Bm1_31380

Sujet: Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 α and GSK-3β. The two isoforms share 97 % sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Pathways: Signalisation PI3K-Akt, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, L'effet Warburg