p53 Protein (AA 1-387, full length) (His-SUMO Tag)

N° du produit ABIN5710532

Détail du produit

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-387

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette p53 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: MEESQSDISL ELPLSQETFS GLWKLLPPED ILPSPHCMDD LLLPQDVEEF FEGPSEALRV SGAPAAQDPV TETPGPVAPA PATPWPLSSF VPSQKTYQGN YGFHLGFLQS GTAKSVMCTY SPPLNKLFCQ LAKTCPVQLW VSATPPAGSR VRAMAIYKKS QHMTEVVRRC PHHERCSDGD GLAPPQHLIR VEGNLYPEYL EDRQTFRHSV VVPYEPPEAG SEYTTIHYKY MCNSSCMGGM NRRPILTIIT LEDSSGNLLG RDSFEVRVCA CPGRDRRTEE ENFRKKEVLC PELPPGSAKR ALPTCTSASP PQKKKPLDGE YFTLKIRGRK RFEMFRELNE ALELKDAHAT EESGDSRAHS SYLKTKKGQS TSRHKKTMVK KVGPDSD

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: P53 (TP53 Produits)

Synonymes: BCC7 Protein, LFS1 Protein, P53 Protein, TRP53 Protein, p53 Protein, Trp53 Protein, brp53 Protein, drp53 Protein, etID22686.5 Protein, fb40d06 Protein, wu:fb40d06 Protein, zgc:111919 Protein, Tp53 Protein, bbl Protein, bfy Protein, bhy Protein, p44 Protein, tp53 Protein, Xp53 Protein, TP53 Protein, tumor protein p53 Protein, cellular tumor antigen p53 Protein, transformation related protein 53 Protein, tumor protein p53 L homeolog Protein, TP53 Protein, CpipJ_CPIJ002758 Protein, Tp53 Protein, tp53 Protein, Trp53 Protein, tp53.L Protein

Sujet: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction ses to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression . Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but ses to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 .

Poids moléculaire: 59.1 kDa

UniProt: P02340

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg