IKBKB anticorps (C-Term)

N° du produit ABIN116875

Détail du produit anti-IKBKB anticorps

Antigène: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKBKB est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Specificité: Anti-IKKb may react non-specifically with other proteins. Control peptide (R1141CP) will compete only with the specific reaction of antiserum with the IKKb subunit.

Purification: Prepared from monospecific antiserum by delipidation and defibrination.

Immunogène: IKKb peptide corresponding to the highly conserved C-terminus region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).

Information d'application

Indications d'application: Suitable for Immunoprecipitation,Western Blot and ELISA. Recommended Dilutions: This product was assayed by immunoblot and found to bereactive against IKKb at a dilution of 1: 1000 followed by reaction with Peroxidaseconjugated Affinity Purified anti-Rabbit IgG [H&L] (Goat). Anti-IKKb is suitable for thedetection by immunoblot of human, mouse and rat IKKb showing an 87 kDa band.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 80 mg/mL (by Refractometry)

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized product at 2-8 °C. After reconstitution, store at -20 °C.

Détails sur IKBKB

Antigène: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Autre désignation: IKBKB / IKKB (IKBKB Produits)

Synonymes: anticorps ikk-beta, anticorps ikk2, anticorps ikkb, anticorps ikkbeta, anticorps IKBKB, anticorps IKKB, anticorps CG4201, anticorps DIK, anticorps DLAK, anticorps DmIKK, anticorps DmIKKBeta, anticorps DmIKKb, anticorps DmIKKbeta, anticorps DmIkkbeta, anticorps Dmel\\CG4201, anticorps Dmikkb, anticorps Dmikkbeta, anticorps IK, anticorps IKK, anticorps IKK-beta, anticorps IKKb, anticorps IKKbeta, anticorps IRD-5, anticorps IRD5, anticorps Ik, anticorps Ikkb, anticorps Ikkbeta, anticorps Ird-5, anticorps Ird5, anticorps LRK, anticorps Lak, anticorps anon-89Bd, anticorps dIKK, anticorps dIKK-beta, anticorps dIKKbeta, anticorps dLak, anticorps dmIKKbeta, anticorps ikk, anticorps ird, anticorps ird5/DmIkk[beta], anticorps IKK2, anticorps NFKBIKB, anticorps AIM-1, anticorps AI132552, anticorps IKK-2, anticorps IKK[b], anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog, anticorps inhibitor of nuclear factor kappa B kinase subunit beta, anticorps I-kappaB kinase beta, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, anticorps inhibitor of kappaB kinase beta, anticorps ikbkb.L, anticorps IKBKB, anticorps ikbkb, anticorps IKKbeta, anticorps Ikbkb

Sujet: NFκB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFκB is negatively modulated by the inhibitory proteins IκB. In turn IκB is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-α and IKK-β which phosphorylate IκB leading to its degradation and the resulting translocation of NFκB to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF-α, endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.Synonyms: I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKK2, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta

ID gène: 3551

NCBI Accession: NP_001177649

UniProt: O14920

Pathways: Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins