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IKBKB anticorps (Tyr199)
IKBKB
Reactivité: Humain, Souris, Rat
IF
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-IKBKB anticorps
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Antigène
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IKBKB
(Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
Épitope
Tous les épitopes à travers IKBKB Anticorps.
Tyr199
Reactivité
Toutes les réactivités sur IKBKB Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur IKBKB Anticorps
Lapin
Clonalité
Toutes les clonalités sur IKBKB Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers IKBKB Anticorps
Cet anticorp IKBKB est non-conjugé
Application
Tous les applications à travers IKBKB Anticorps.
Immunofluorescence (IF)
Specificité
IKK-β Antibody detects endogenous levels of total IKK-β protein.
Purification
Affinity chromatography
Immunogène
Synthesized non-phosphopeptide derived from human IKK-beta around the phosphorylation site of tyrosine 199 (Q-K-YP-T-V)
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Information d'application
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Indications d'application
Immunofluorescence: 1/100 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Détails sur IKBKB
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Antigène
IKBKB
(Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
Autre désignation
IKBKB / IKKB (IKBKB Produits )
Synonymes
anticorps ikk-beta, anticorps ikk2, anticorps ikkb, anticorps ikkbeta, anticorps IKBKB, anticorps IKKB, anticorps CG4201, anticorps DIK, anticorps DLAK, anticorps DmIKK, anticorps DmIKKBeta, anticorps DmIKKb, anticorps DmIKKbeta, anticorps DmIkkbeta, anticorps Dmel\\CG4201, anticorps Dmikkb, anticorps Dmikkbeta, anticorps IK, anticorps IKK, anticorps IKK-beta, anticorps IKKb, anticorps IKKbeta, anticorps IRD-5, anticorps IRD5, anticorps Ik, anticorps Ikkb, anticorps Ikkbeta, anticorps Ird-5, anticorps Ird5, anticorps LRK, anticorps Lak, anticorps anon-89Bd, anticorps dIKK, anticorps dIKK-beta, anticorps dIKKbeta, anticorps dLak, anticorps dmIKKbeta, anticorps ikk, anticorps ird, anticorps ird5/DmIkk[beta], anticorps IKK2, anticorps NFKBIKB, anticorps AIM-1, anticorps AI132552, anticorps IKK-2, anticorps IKK[b], anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog, anticorps inhibitor of nuclear factor kappa B kinase subunit beta, anticorps I-kappaB kinase beta, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, anticorps inhibitor of kappaB kinase beta, anticorps ikbkb.L, anticorps IKBKB, anticorps ikbkb, anticorps IKKbeta, anticorps Ikbkb
Sujet
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.Synonyms: I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKK2, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta
ID gène
3551
NCBI Accession
NP_001547
UniProt
O14920
Pathways
Signalisation NF-kappaB , Signalisation RTK , TCR Signaling , Signalisation TLR , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Production of Molecular Mediator of Immune Response , Hepatitis C , Toll-Like Receptors Cascades , BCR Signaling , Ubiquitin Proteasome Pathway , S100 Proteins
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