AKT1
Reactivité: Humain
WB, IHC, IF, IP
Hôte: Lapin
Monoclonal
unconjugated
Indications d'application
WB,1:500 - 1:2000,IP,1:20 - 1:50
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Store at -20°C. Avoid freeze / thaw cycles.
Xing, Yu, Zhang, Luo, Lei, Huang, Lin, Huang, Huang, Nong, Zhou, Wei et al.: "Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR ..." dans: International journal of molecular sciences, Vol. 19, Issue 6, (2018) (PubMed).
Dinesh, Rasool et al.: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." dans: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).
Wang, Huang, Zhang, Hou, Liu, Chen, Zhu, Zhang: "Toosendanin suppresses oncogenic phenotypes of human gastric carcinoma SGC‑7901 cells partly via miR‑200a‑mediated downregulation of β-catenin pathway." dans: International journal of oncology, Vol. 51, Issue 5, pp. 1563-1573, (2018) (PubMed).
Wu, Yu, Wang, Zhang, Shang, Yao, Cao: "Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway." dans: Biomedicine & pharmacotherapy, Vol. 100, pp. 176-183, (2018) (PubMed).
Zou, Liao, Fu, Zhao, Chen, Zhang: "MicroRNA-30c-5p ameliorates hypoxia-reoxygenation-induced tubular epithelial cell injury via HIF1α stabilization by targeting SOCS3." dans: Oncotarget, Vol. 8, Issue 54, pp. 92801-92814, (2017) (PubMed).
Li, Zhao, Chen, Fu, Shi, Liu, Liu, Xiong, Liu, Yang, Xiao: "Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes." dans: Bioorganic & medicinal chemistry, Vol. 25, Issue 24, pp. 6605-6613, (2017) (PubMed).
Chen, Hua, Ze, Wang, Wei: "The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells." dans: International journal of ophthalmology, Vol. 10, Issue 2, pp. 179-185, (2017) (PubMed).
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.,AKT,CWS6,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA,AKT1,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Cancer,Signal Transduction,G protein signaling,Kinase,Serine/threonine kinases,PI3K-Akt Signaling Pathway,mTOR Signaling Pathway,Protein Kinase C Signaling Pathway,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Cell Cycle,G1/S Checkpoint,Cell Adhesion,Microtubules,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,AMPK Signaling Pathway,Insulin Receptor Signaling Pathway,Warburg Effect,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,IL-6 Receptor Signaling Pathway,NF-kB Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Cardiovascular,Angiogenesis,AKT1