AKT1 anticorps

N° du produit ABIN7251032

Détail du produit anti-AKT1 anticorps

Antigène: AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Synthesized peptide derived from human Akt around the non-phosphorylation site of Tyr326.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur AKT1

Antigène: AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))

Autre désignation: AKT1 (AKT1 Produits)

Synonymes: anticorps AKT, anticorps CWS6, anticorps PKB, anticorps PKB-ALPHA, anticorps PRKBA, anticorps RAC, anticorps RAC-ALPHA, anticorps Akt, anticorps Rac, anticorps PKB/Akt, anticorps PKBalpha, anticorps AKT/PKB, anticorps AKT1, anticorps Akt/PKB, anticorps Akt1, anticorps CG4006, anticorps D-Akt, anticorps DAKT1, anticorps DAKT1/PKB, anticorps DAkt, anticorps DAkt1, anticorps DPKB, anticorps DRAC-PK, anticorps DRAC-PK66, anticorps DRAC-PK85, anticorps Dakt, anticorps Dakt1, anticorps Dmel\\CG4006, anticorps Dpkb, anticorps PKB/AKT, anticorps PKB/dAKT, anticorps RacPK, anticorps akt, anticorps akt1, anticorps dAKT, anticorps dAKT/dPKB, anticorps dAKT1, anticorps dAkt, anticorps dAkt/PKB, anticorps dAkt1, anticorps dPKB, anticorps dakt, anticorps dakt1, anticorps l(3)04226, anticorps l(3)89Bq, anticorps p-Akt, anticorps pAkt, anticorps ACT-5, anticorps akt-1, anticorps pkb, anticorps v-akt, anticorps v-akt1, anticorps xAct, anticorps ATAKT1, anticorps F18A8.2, anticorps F18A8_2, anticorps K+ transporter 1, anticorps POTASSIUM TRANSPORTER, anticorps AKT serine/threonine kinase 1, anticorps thymoma viral proto-oncogene 1, anticorps CG4006 gene product from transcript CG4006-RE, anticorps actin beta, anticorps v-akt murine thymoma viral oncogene homolog 1 S homeolog, anticorps v-akt murine thymoma viral oncogene homolog 1, anticorps K+ transporter 1, anticorps Serine/threonine-protein kinase akt-1, anticorps AKT1, anticorps Akt1, anticorps ACTB, anticorps akt1.S, anticorps akt1, anticorps KT1, anticorps akt-1

Sujet: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.

Poids moléculaire:

Observed_MW: 60 kDa

Calculated_MW: 56 kDa

UniProt: P31749

Pathways: Signalisation PI3K-Akt, Signalisation RTK, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Water Deprivation, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGFR1 Specific Signals, VEGF Signaling, L'effet Warburg